ARTHUR B. SCHNEIDER, M.D., Ph.D.; MURRAY J. FAVUS, M.D.; MAX E. STACHURA, M.D.; MARGARET J. ARNOLD, R.N.; LAWRENCE A. FROHMAN, M.D.
An increased occurrence of salivary tumors was observed in 1922 patients who received radiation to the tonsils and nasopharynx. Twenty-seven tumors, 19 benign and eight malignant, were found in this group as compared with an expected 0.2 malignant and < 1 benign tumor. The latent period between the initial radiation treatment and diagnosis ranged from 7 to 32 years. After the first 15 years the incidence (77 cases/105 subjects/year) has remained constant and shows no indication of declining. Continued observation for salivary gland tumors is therefore indicated for subjects who received childhood irradiation.
SCHNEIDER AB, FAVUS MJ, STACHURA ME, et al. Salivary Gland Neoplasms as a Late Consequence of Head and Neck Irradiation. Ann Intern Med. 1977;87:160–164. doi: 10.7326/0003-4819-87-2-160
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Published: Ann Intern Med. 1977;87(2):160-164.
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