M. DÍAZ-CURIEL, M.D.; J.M. CASTRILLO, M.D.; A. RAPADO, M.D.
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To the editor: The value of plasma chloride in the differential diagnosis of hypercalcemia has been reported since 1963 (1). In 1974, Palmer and associates (2), and later on, other authors (3, 4) have confirmed the value of the chloride/phosphorus ratio (Cl/PO4) to differentiate primary hyperparathyroidism from other causes of hypercalcemia. More recently Pak and Townsend (5), however, have studied the Cl/PO4 ratio in patients with primary hyperparathyroidism and in control subjects; they found significant differences, although a wide overlap of values, in the two groups. This finding questions the usefulness of the ratio.
We have studied the Cl/PO4 ratio
DÍAZ-CURIEL M, CASTRILLO J, RAPADO A. Chloride/Phosphorus Ratio and Hyperparathyroidism. Ann Intern Med. ;87:251. doi: 10.7326/0003-4819-87-2-251
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Published: Ann Intern Med. 1977;87(2):251.
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