GENE H. STOLLERMAN, M.D.
This content is PDF only. Please click on the PDF icon to access.
The pathogenesis of rheumatic fever and rheumatic carditis is still obscure despite a voluminous literature on group A streptococcal immunology (1). The popular notion, however, that rheumatic inflammation may be due to cross-reactivity between streptococcal antigens and cardiac tissues has loomed as a formidable deterrence to attempts to prepare a streptococcal vaccine. Several recent studies have opened up new technical approaches to the clean separation of the type-specific M protein determinants from the streptococcal antigens responsible for cross-reactions with heart and other tissues. These studies offer fresh approaches toward solving the riddle of rheumatic carditis and they offer some new
STOLLERMAN GH. Streptococcal Immunology: Protection Versus Injury. Ann Intern Med. 1978;88:422–423. doi: 10.7326/0003-4819-88-3-422
Download citation file:
Published: Ann Intern Med. 1978;88(3):422-423.
Infectious Disease, Streptococcal Infections.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use