JACK M. GWALTNEY Jr., M.D., F.A.C.P.; PATRICIA B. MOSKALSKI; J. OWEN HENDLEY, M.D.
Rhinovirus was transmitted from experimentally infected volunteers (donors) to susceptible recipients and the efficiencies of spread by hand-to-hand contact and large- and small-particle aerosols compared. Transmission of infection was very efficient by the hand route: 11 of 15 hand-contact exposures initiated infection, compared with one of 12 large-particle (P < 0.005) and none of 10 small-particle (P < 0.005) exposures. Rhinovirus was present in nine of 18 (50%) nasal swab specimens, 28 of 43 (65%) hand rinses, and seven of 18 (39%) saliva specimens of donors; geometric mean titers of positive specimens were 101.5, 101.4, and 101.2 tissue culture infectious dose 50/ml (TCID50/ml), respectively. Rhinovirus was present in 20 of 43 (46%) recipient hand rinses, with a geometric mean titer of 10l.4TCID50/ml. Virus on donors' hands was transferred to recipients' fingers during 20 of 28 (71%) 10-second hand-contact exposures. These findings support the concept that hand contact/self-inoculation may be an important natural route of rhinovirus transmission.
GWALTNEY JM, MOSKALSKI PB, HENDLEY JO. Hand-to-Hand Transmission of Rhinovirus Colds. Ann Intern Med. 1978;88:463–467. doi: 10.7326/0003-4819-88-4-463
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Published: Ann Intern Med. 1978;88(4):463-467.
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