HARMAR D. BRERETON, M.D.; JOSEPH F. O'DONNELL, M.D.; C. HARRY KENT, M.D.; MARY MATTHEWS, M.D.; N. REED DUNNICK, M.D.; RALPH E. JOHNSON, M.D.
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Meningeal carcinomatosis is an uncommon but well-documented event in the course of various neoplasms (1). However, the accurate diagnosis or anticipation of meningeal carcinomatosis, unlike meningeal leukemia
(2), has made no difference in patient survival. Further, the frequency with which meningeal carcinomatosis occurs in most carcinomas is sufficiently obscure, and most likely very low, that prophylactic treatment of this sanctuary site would not be warranted. However, with improved treatment and prolonged survival for some patients with small-cell lung cancer (3), we have encountered a 9% incidence of spinal meningeal carcinomatosis in this disease.
Fifty-eight consecutive patients with small-cell carcinoma of
BRERETON HD, O'DONNELL JF, KENT CH, et al. Spinal Meningeal Carcinomatosis in Small-Cell Carcinoma of the Lung. Ann Intern Med. 1978;88:517–519. doi: https://doi.org/10.7326/0003-4819-88-4-517
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Published: Ann Intern Med. 1978;88(4):517-519.
Hematology/Oncology, Lung Cancer, Neurology, Pulmonary/Critical Care.
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