C. KENT SMITH, M.D., F.A.C.P.; DAVID T. DURACK, M.B., D.Phil., F.A.C.P., F.R.A.C.P.
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The first monoamine oxidase inhibitors used clinically were developed as congeners of isoniazid after mood elevation was noted in patients taking isoniazid for treatment of tuberculosis (1). Monoamine oxidase inhibitors are effective in the treatment of depression and certain phobic anxiety states, but their use is limited because hypertensive crises may occur when patients taking monoamine oxidase inhibitors eat foods rich in monoamines, especially tyramine (2). It is well known that certain cheeses and red wines may trigger this reaction (3). Although isoniazid is closely related structurally to some monoamine oxidase inhibitors, patients taking isoniazid are not regarded as being
SMITH CK, DURACK DT. Isoniazid and Reaction to Cheese. Ann Intern Med. 1978;88:520–521. doi: 10.7326/0003-4819-88-4-520
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Published: Ann Intern Med. 1978;88(4):520-521.
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