KENNETH D. LEMPERT, M.D.
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To the editor: I read with interest the report of a possible pathogenic relation between monoclonal gammopathy and hereditary spherocytosis (Ann Intern Med 88:45-46, 1978). The proposal by Schafer and associates that chronic stimulation of the reticuloendothelial system might foster the neoplastic transformation of immunocytes is intriguing. I too have seen a patient with both disorders.
An 80-year-old woman was referred to the University of Wisconsin Hospitals for the evaluation of anemia of 4 years' duration. Iron supplementation had not improved her condition. She had not had a splenectomy. Her hematocrit was 20% and reticulocyte count 6.1%. Peripheral smear showed
LEMPERT KD. Gammopathy and Spherocytosis. Ann Intern Med. ;89:145–146. doi: 10.7326/0003-4819-89-1-145_2
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Published: Ann Intern Med. 1978;89(1):145-146.
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