CHARLES EIL, M.D., PH.D.; BRUCE T. ADORNATO, M.D.
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To the editor: Multifocal eosinophilic granuloma (Hand-Schüller-Christian disease) often produces lytic lesions of the skeletal system. Scintiscanning with bone-seeking agents is thought to be a usually reliable and early means of detecting such lesions (1, 2). We have recently reported (3) the case of a patient with multifocal eosinophilic granuloma who suffered extradural C7 to T1 nerve root compression associated with a radiotomographically demonstrable T1 vertebral body lesion but had a negative technetium-99m-diphosphonate bone scan.
We report here the case of a second patient with extradural spinal root compression with histologically verified multifocal eosinophilic granuloma in whom conventional radiographs, computerized
EIL C, ADORNATO BT. Caution on Bone Scans in Eosinophilic Granuloma. Ann Intern Med. ;89:289. doi: 10.7326/0003-4819-89-2-289_2
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Published: Ann Intern Med. 1978;89(2):289.
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