STEVEN J. SANTNER, B.S.; FREDERICK T. MURRAY, M.D.; BONNIE DAVIS, B.S.; RICHARD J. SANTEN, M.D., F.A.C.P.
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The pulsatile nature of luteinzing hormone (LH) and, to a lesser extent, follicle-stimulating hormone (FSH) secretion requires that integrated gonadotrophin concentrations be ascertained to accurately assess gonadotrophin status in patients (1-4). Measurements of LH and FSH in precisely timed 3-to-24 h urine collections (5-6) or in serial blood samples during 3-to-6 h (2, 7) are effective means of integrating pulsatile gonadotrophin fluctuations. However, these methods are expensive because urine requires extraction and concentration before radioimmunoassay and serial blood sampling generates a large number of specimens to be run individually. When dynamic testing with luteinzing hormone-releasing hormone (LH-RH) or clomiphene is
SANTNER SJ, MURRAY FT, DAVIS B, SANTEN RJ. The Integrated Gonadotrophin Test. Ann Intern Med. ;89:512–513. doi: 10.7326/0003-4819-89-4-512
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Published: Ann Intern Med. 1978;89(4):512-513.
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