MARTIN J. INWOOD, M.D., F.R.C.P.(C); BRUCE ZULIANI, B.A., R.T.
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Acute intravascular hemolytic transfusion reactions are most often due to the transfusion of ABO incompatible erythrocytes (1). However, severe intravascular hemolysis can also be due to transfusion of nonhomologous ABO plasma, platelet concentrate, or group O whole blood to either A, B, or AB recipients (2-4). Finally, the production of autoimmune ABO antibodies also causes severe intravascular hemolysis (5). When there is no alternative to transfusing group O blood to group A, B, or AB recipients, the clinician will recommend that packed cells be used in order to avoid unnecessary transfer of group O plasma containing the inappropriate ABO antibody.
INWOOD MJ, ZULIANI B. Anti-A Hemolytic Transfusion with Packed O Cells. Ann Intern Med. ;89:515–516. doi: 10.7326/0003-4819-89-4-515
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Published: Ann Intern Med. 1978;89(4):515-516.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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