DAVID G. BORENSTEIN, M.D.; W. BRUCE FYE, M.D.; FRANK C. ARNETT, M.D., F.A.C.P.; MARY BETTY STEVENS, M.D., F.A.C.P.
Five patients with clinically overt myocarditis in the setting of systemic lupus erythematosus were analyzed in terms of associated clinical and serologic features. Myositis and antibodies to nuclear ribonucleoprotein (RNP) were present in all. A retrospective review in 140 consecutive patients with systemic lupus erythematosus, including three of these five, showed a highly significant association of myocarditis with myositis (P < 0.0005). The presence of antibodies to RNP in this small group did not attain statistical significance (P < 0.10). The pathologic findings in the one patient who died showed similar patterns of inflammation in both cardiac and skeletal muscle, suggesting the possibility of a generalized inflammatory process directed against striated muscle. Furthermore, although anti-RNP antibodies were found uniformly in these patients, their significance remains to be defined.
BORENSTEIN DG, FYE WB, ARNETT FC, et al. The Myocarditis of Systemic Lupus Erythematosus: Association with Myositis. Ann Intern Med. 1978;89:619–624. doi: https://doi.org/10.7326/0003-4819-89-5-619
Download citation file:
Published: Ann Intern Med. 1978;89(5_Part_1):619-624.
Cardiology, Lupus Erythematosus, Rheumatology.
Results provided by:
Copyright © 2020 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use