GEORGE CRAWFORD, M.D.; FRANK BRANCATO, Ph.D.; KING K. HOLMES, M.D.
Group A beta-hemolytic streptococci were isolated from 49 (10.4%) of 472 patients with pharyngitis. Throat culture results, interpreted by five observers of varying experience, showed the mean sensitivity, specificity, and predictive value of a positive Gram-stained smear of pharyngeal secretions as 73%, 96%, and 71%. Assignment to a high-risk group by clinical algorithm gave sensitivity, specificity, and predictive value of only 45%, 83%, and 23%. The Gram-stained smear is the most accurate method of early diagnosis of streptococcal pharyngitis.
CRAWFORD G, BRANCATO F, HOLMES KK. Streptococcal Pharyngitis: Diagnosis by Gram Stain. Ann Intern Med. ;90:293–297. doi: 10.7326/0003-4819-90-3-293
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Published: Ann Intern Med. 1979;90(3):293-297.
Infectious Disease, Streptococcal Infections.
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