GARY L. LATTIMER, M.D.; LUTHER V. RHODES III, M.D.; JOHN S. SALVENTI, Ph.D.; JOHN P. GALGON, M.D.; VICTOR STONEBRAKER; SHARON BOLEY, B.S.; GARY HAAS
Clinical, pulmonary, and serologic findings in Legionnaires who attended the 1976 American Legion Convention in Philadelphia were studied 2 years after the Legionnaires' disease epidemic there. All 31 survivors of Legionnaires' disease studied became ill within 2 weeks after the convention, and 18 had not fully recovered 2 years after the epidemic. Twenty-five (28%) of 90 additional Legionnaires exposed at the convention but not diagnosed as having Legionnaires' disease became ill during the same time interval; five of these had symptoms during the next 2 years. Survivors had decreased diffusion capacities measured by the carbon monoxide single-breath method. These differences could not be accounted for by ventilation abnormalities or concurrent illness. Significant levels of IgG or IgM antibodies persisted in 94% of survivors of Legionnaires' disease and in 53% of Legionnaires exposed at the convention, which suggests a high prevalence of subclinical infection. Persistence of IgM antibody raises the question of latency or subclinical infection as part of the natural history of Legionnaires' disease.
LATTIMER GL, RHODES LV, SALVENTI JS, et al. The Philadelphia Epidemic of Legionnaire's Disease: Clinical, Pulmonary, and Serologic Findings Two Years Later. Ann Intern Med. 1979;90:522–526. doi: https://doi.org/10.7326/0003-4819-90-4-522
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Published: Ann Intern Med. 1979;90(4):522-526.
Infectious Disease, Pulmonary/Critical Care.
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