KENNETH W. HEDLUND, M.D.; VIRGINIA G. McGANN, Ph.D.; DIANA S. COPELAND, D.V.M.; STEPHEN F. LITTLE, B.S.; RICHARD G. ALLEN, Ph.D.
Female AKR/J mice were challenged with the Washington strain of Legionnaires' disease (LD) bacteria. Nonimmunized mice inoculated intraperitoneally with 2 X 108 colony forming units became ill within 4 h and died within 24 h. Progressive histopathologic changes initiated as early as 2 h after inoculation involved the lymphoid organs, the crypts of the small intestine, and the liver. Necrosis with minimal inflammatory cell reaction was the primary lesion. Immunization with a soluble LD bacterial antigen failed to prevent illness but protected against death and development of abnormal histologic changes.
HEDLUND KW, McGANN VG, COPELAND DS, et al. Immunologic Protection Against the Legionnaires' Disease Bacterium in the AKR/J Mouse. Ann Intern Med. 1979;90:676–679. doi: 10.7326/0003-4819-90-4-676
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Published: Ann Intern Med. 1979;90(4):676-679.
Infectious Disease, Pulmonary/Critical Care.
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