BRUCE H. PETERSEN, Ph.D.; TERRENCE J. LEE, M.D.; RALPH SNYDERMAN, M.D.; GEO. F. BROOKS, M.D.
We summarize data from 24 previously described or newly diagnosed cases of homozygous deficiency of the sixth, seventh, or eighth components of complement. Thirteen of 24 patients had at least one episode, and usually two or more episodes of Neisseria meningitidis or Neisseria gonorrhoeae bacteremia, or both. Deficiency of C6, C7, or C8 is a meaningful risk factor for repeated neisserial bacteremia; conversely, hemolytic complement studies are indicated in patients who develop recurrent neisserial infections. When a person with C6, C7, or C8 deficiency is identified, family members should also be studied.
PETERSEN BH, LEE TJ, SNYDERMAN R, BROOKS GF. Neisseria meningitidis and Neisseria gonorrhoeae Bacteremia Associated with C6, C7, or C8 Deficiency. Ann Intern Med. 1979;90:917–920. doi: 10.7326/0003-4819-90-6-917
Download citation file:
Published: Ann Intern Med. 1979;90(6):917-920.
Infectious Disease, Multi-Organ Failure and Sepsis, Pulmonary/Critical Care.
Results provided by:
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use