WILLIAM A. BLATTNER, M.D.; JACK H. DEAN, Ph.D.; JOSEPH F. FRAUMENI Jr., M.D.
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In 1969 we reported an aggregation of chronic lymphocytic leukemia in three siblings, together with immune defects that may have contributed to the familial predisposition (1). This follow-up study extends the range of B-cell neoplasms and immune defects occurring in this family (Figure 1).
In 1974, the 42-year-old daughter (III-2) of the proband developed stage III-A, nodular, poorly differentiated lymphocytic lymphoma, which responded to cyclophosphamide, vincristine, and prednisone. She relapsed in June 1978 and responded to a second course of the same drugs. As a child, numerous vaccinations were unsuccessful; but subsequently, she showed no unusual susceptibility to infection.
BLATTNER WA, DEAN JH, FRAUMENI JF. Familial Lymphoproliferative Malignancy: Clinical and Laboratory Follow-Up. Ann Intern Med. 1979;90:943–944. doi: 10.7326/0003-4819-90-6-943
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Published: Ann Intern Med. 1979;90(6):943-944.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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