ROBERT FOX, M.D.; ANDREI CALIN, M.D.; ROBERT C. GERBER, M.D.; DAVID GIBSON, M.D.
To assess the natural history of Reiter's disease, we evaluated 131 consecutive patients at a university clinic or at a community center. One hundred twenty-two patients (93%) were available for follow-up at a mean of 5.6 years. The results showed that there were no major differences between patients at the two centers; at follow-up, 101 (83%) had some disease activity, 27 (22%) had annoying symptoms, 42 (34%) had sustained disease activity, 19 (16%) had had to change jobs, and 13 (11%) were unemployable; there were no major differences between the 19 (15%) females and 112 (85%) males or between the HLA-B27-positive (83%) and -negative (17%) patients, except for increased prevalence of sacroiliitis and chronic uveitis in HLA-B27 -positive patients; and, at entry, only increased heel disease differentiated those destined to have a poor prognosis. Most patients with Reiter's syndrome have persisting symptoms that can lead to chronic disability.
FOX R, CALIN A, GERBER RC, GIBSON D. The Chronicity of Symptoms and Disability in Reiter's Syndrome: An Analysis of 131 Consecutive Patients. Ann Intern Med. 1979;91:190–193. doi: 10.7326/0003-4819-91-2-190
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Published: Ann Intern Med. 1979;91(2):190-193.
Infectious Disease, Rheumatology.
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