H. ALEXANDER WILSON, M.D.; GORDON D. McLAREN, M.D.; HARVEY J. DWORKEN, M.D.; KAMRAN TEBBI, M.D.
Transient pure red-cell aplasia is a rare complication of persistent acute hepatitis. We have investigated possible mechanisms for marrow suppression in one such patient who developed erythroid aplasia in the course of transfusion-related hepatitis. The patient's lymphocytes, obtained during the acute illness, markedly inhibited erythroid colony formation by donor marrow. After the patient recovered, remission lymphocytes in co-culture did not inhibit colony formation. No reversible suppression was demonstrable by addition of patient serum. These observations suggest that hematocytopenias associated with hepatitis may result from cell-mediated suppression induced by hepatic injury.
WILSON HA, McLAREN GD, DWORKEN HJ, et al. Transient Pure Red-Cell Aplasia: Cell-Mediated Suppression of Erythropoiesis Associated with Hepatitis. Ann Intern Med. 1980;92:196–198. doi: 10.7326/0003-4819-92-2-196
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Published: Ann Intern Med. 1980;92(2_Part_1):196-198.
Gastroenterology/Hepatology, Hematology/Oncology, Liver Disease, Red Cell Disorders.
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