DAVID KAPLAN, M.D.
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To the editor: In his discussion in the National Institutes of Health conference "Systemic Lupus Erythematosus: Evolving Concepts" (1), Dr. Klippel compares several regimens for the treatment of lupus nephritis: unspecified but modest amounts of prednisone with either azathioprine, cyclophosphamide, azathioprine plus cyclophosphamide, or itermittent intravenous cyclophosphamide, and modest amounts of prednisone alone. He concludes that azathioprine plus cyclophosphamide and intravenous cyclophosphamide may "reduce the progression of renal disease" in patients with systemic lupus erythematosus.
His data, however, may be organized as in Table 1, which considers only the preservation of renal function and suggests the following conclusions: cytotoxic drugs
KAPLAN D. Regimens for Treatment of Lupus Nephritis. Ann Intern Med. ;92:437–438. doi: 10.7326/0003-4819-92-3-437_3
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Published: Ann Intern Med. 1980;92(3):437-438.
Lupus Erythematosus, Rheumatology.
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