JAMES D. WEBSTER, M.D.; THOMAS F. PARKER, B.S. M.D.; AL C. ALFREY, M.D.; W. R. SMYTHE, Ph.D.; HIDEO KUBO, Ph.D.; GEORGE NEAL; ALAN R. HULL, M.D.
Nickel intoxication was observed in a group of 23 dialyzed patients when leaching of nickel-plated stainless steel water heater tank contaminated the dialysate. Symptoms occurred during and after dialysis at plasma nickel concentrations of approximately 3 mg/L. Symptoms included nausea (37 of 37), vomiting (31 of 37), weakness (29 of 37), headache (22 of 37), and palpitation (two of 37). Remission of symptoms occurred spontaneously, generally 3 to 13 hours after cessation of dialysis. The evidence indicated that the nickel became bound in the plasma after crossing the membrane, resulting in a higher concentration in the plasma than in the dialysate and preventing its removal by dialysis.
WEBSTER JD, PARKER TF, ALFREY AC, et al. Acute Nickel Intoxication by Dialysis. Ann Intern Med. 1980;92:631–633. doi: 10.7326/0003-4819-92-5-631
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Published: Ann Intern Med. 1980;92(5):631-633.
Emergency Medicine, Nephrology, Renal Replacement Therapy.
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