I. JON RUSSELL, M.D.
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To the editor: Since sulindac was introduced in November 1978, a number of adverse reactions have been reported, including congestive heart failure, Stevens-Johnson syndrome, toxic epidermal necrolysis, bone marrow depression, thrombocytopenia, leukopenia, gastrointestinal perforation, hepatitis, nephropathy and a number of ocular disorders (1-3). The following case illustrates a reversible systemic hypersensitivity reaction due to sulindac.
A 26-year-old woman complaining of arthralgias and sinus congestion was referred to the rheumatic disease section with a presumptive diagnosis of systemic lupus erythematosus. She had a 6-year history of alopecia, bimalar sun-sensitive rash, intermittent pleurisy, arthritis, biological false-positive test for syphilis, and positive antinuclear
RUSSELL IJ. Reaction to Sulindac. Ann Intern Med. ;92:716–717. doi: 10.7326/0003-4819-92-5-716_3
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Published: Ann Intern Med. 1980;92(5):716-717.
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