MARCEL E. CONRAD, M.D.
This content is PDF only. Please click on the PDF icon to access.
To the editor: In the December issue, Hoofnagle and colleagues (1) conclude that immune serum gamma globulin (ISG) preparations produce passive-active immunity when administered after exposure and suggest that when older lots of ISG were administered before exposure, they acted by inducing active immunity. Further they speculate that with the introduction of hepatitis B surface antigen (HBsAg) screening of donors in 1972, the immunogenic effect of serum globulin probably disappeared for hepatitis B. Their data and that of others provide reasonable support for the conclusion that after exposure, ISG administration acts by passive-active immunization. Their other conclusions, however, deserve closer
CONRAD ME. Prevention of Hepatitis with Gamma Globulin. Ann Intern Med. 1980;92:868–871. doi: https://doi.org/10.7326/0003-4819-92-6-868
Download citation file:
Published: Ann Intern Med. 1980;92(6):868-871.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use