GUY DECAUX, M.D.; FRANÇOISE GENETTE, M.D.; JEAN MOCKEL, M.D., Ph.D.
Low blood urea levels are a common finding in the syndrome of inappropriate secretion of antidiuretic hormone (1). Although they usually are attributed to body fluid dilution, some have suggested that they may also result from excessive urinary losses (2). To investigate this point we studied prospectively the relation between serum sodium levels, blood urea, and urinary urea in seven patients with the syndrome of inappropriate secretion of antidiuretic hormone. The data confirmed the suspected increase in urea urinary losses which, together with body fluid dilution, explained the low urea blood levels in our patients.
Seven patients with asymptomatic hyponatremia
DECAUX G, GENETTE F, MOCKEL J. Hypouremia in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone. Ann Intern Med. 1980;93:716–717. doi: 10.7326/0003-4819-93-5-716
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Published: Ann Intern Med. 1980;93(5):716-717.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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