EDWARD B. LEAHEY JR, M.D.
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Quinidine has been the prototype of antiarryhthmic drug since it was introduced into clinical practice in 1918, and it is widely used for treatment of both atrial and ventricular arrhythmias. Patients given quinidine frequently are also receiving a digitalis preparation because they have ventricular failure as well as cardiac arrhythmia, and because digitalis is frequently used to slow the ventricular response to atrial fibrillation when quinidine is used to convert the fibrillation to sinus rhythm. Despite the frequent combined administration of these two drugs, interaction between quinidine and digoxin was only recognized in 1978 (1-3).
Radioimmunoassay of serum digoxin concentration
LEAHEY EB. Digoxin-Quinidine Interaction: Current Status. Ann Intern Med. ;93:775–776. doi: 10.7326/0003-4819-93-5-775
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Published: Ann Intern Med. 1980;93(5):775-776.
Cardiology, Rhythm Disorders and Devices.
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