GORDON R. MCKINNEY, PH.D.
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To the editor: There is, I believe, some erroneous information on Cefadroxil in Table 1 of Bennett and associates' article (1) on drug therapy in renal failure. Rather than 8 hours, the "Normal Dose Interval" should read 12 or 24 hours. The package insert shows that the approved dosing regimen is either once or twice daily.
Also, the package insert contains a table showing the dose adjustment, based on creatinine clearance rates, in patients with renal failure. In effect, that table indicates that the 12-hour dosing interval may still be used even in patients with a creatinine clearance rate as
MCKINNEY GR. Correction: Cefadroxil Dosing Interval. Ann Intern Med. ;93:784. doi: 10.7326/0003-4819-93-5-784_1
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Published: Ann Intern Med. 1980;93(5):784.
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