LESTER A. TEMKIN, B.S.; WILLIAM W. MCCLOSKEY, PHARM.D.
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To the editor: The article "Amikacin Serum Concentrations; Prediction of Levels and Dosage Guidelines" (1) is routinely referred to for determining appropriate dosages for aminoglycoside antibiotics. In their study, the authors calculate creatinine clearance by a modification of the method of Cockcroft and Gault (2) that incorporates a standard ideal body weight of 70 kg: C(c) cr male = 140 - ageserum creatinine.
The authors provide a convenient dosing chart for aminoglycosides in Figure 4 of their article. However, the formula for creatinine clearance is erroneously reproduced in the chart as
C(c) cr male = 140 - age/serum creatinine.
TEMKIN LA, MCCLOSKEY WW. Correction: Amikacin and Creatinine Clearance. Ann Intern Med. ;93:784. doi: 10.7326/0003-4819-93-5-784_4
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Published: Ann Intern Med. 1980;93(5):784.
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