DONALD KAYE, M.D.
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The article in this issue by Rajashekaraiah and co-workers (1) raises the issue of the clinical significance of a laboratory phenomenon, tolerance of Staphylococcus aureus to beta-lactam antibiotics. Three questions must be addressed in evaluating the observations of these authors, who concluded that tolerance of S. aureus to penicillinase-resistant penicillins and cephalosporins leads to poor results in therapy of S. aureus endocarditis. They are [1] what exactly is tolerance, and how frequently does it occur? [2] What is the evidence that it has clinical significance? [3] What should be the approach to patients with endocarditis caused by tolerant S. aureus?
KAYE D. The Clinical Significance of Tolerance of Staphylococcus aureus. Ann Intern Med. 1980;93:924–926. doi: 10.7326/0003-4819-93-6-924
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Published: Ann Intern Med. 1980;93(6):924-926.
DOI: 10.7326/0003-4819-93-6-924
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