OLOF FORSSMAN, M.D.; SVEND-AAGE JOHNSEN, M.D.; BARBRO CARLSSON, M.D.
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To the editor: The recent article by Gonwa and associates (1) does not consider the possible mechanisms by which some patients with analgesic-associated nephropathy develop a cell carcinoma of the urinary tract. Because disorders with immunodeficiency have an higher incidence of malignancies than expected and phenacetin may exert an influence on the local immune defense, we studied the excretion of secretory IgA in fresh urinary specimens of three patients with analgesic-associated nephropathy, and tumor, using an ELISA method (2). The values obtained were within the normal limits, although the patient with the most advanced nephropathy had a value just at
FORSSMAN O, JOHNSEN S, CARLSSON B. Secretory Immunoglobulin A and Analgesic-Associated Diseases. Ann Intern Med. ;94:140. doi: 10.7326/0003-4819-94-1-140_1
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Published: Ann Intern Med. 1981;94(1):140.
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