COSTAN W. BERARD, M.D.; MARK H. GREENE, M.D.; ELAINE S. JAFFE, M.D.; IAN MAGRATH, M.B.; JOHN ZIEGLER, M.D.
Epidemiologic studies show that non-Hodgkin's lymphomas tend to develop after prolonged antigenic stimulation, after loss of normal regulation of lymphoid proliferation, or especially after both processes. Study of these tumors in vitro has greatly increased understanding of their pathophysiology and has provided a conceptual framework for their morphologic diversity. Lymphomas are now understood to be expanded clones of their normal counterparts. The anatomic location, phenotypic characteristics, proliferative capacity, and functional capabilities of the neoplasm often reflect those of the equivalent normal cells. If neoplastic transformation can occur at any stage of lymphoid differentiation, then it is theoretically possible that neoplastic lymphocytes may respond, or could be induced to respond, to normal regulatory influences. Further study of selective cytotoxicity may reveal exploitable differences among lymphocytic subpopulations and permit more rational choices of therapy. Of major aid to future clinical trials should be the recent consensus on nomenclature by an international panel of experts.
BERARD CW, GREENE MH, JAFFE ES, et al. A Multidisciplinary Approach to Non-Hodgkin's Lymphomas. Ann Intern Med. 1981;94:218–235. doi: https://doi.org/10.7326/0003-4819-94-2-218
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Published: Ann Intern Med. 1981;94(2):218-235.
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