J. A. CARNEY, M.D., Ph.D.; A. B. HAYLES, M.D.; A. G. E. PEARSE, M.D.; H. O. PERRY, M.D.; G. W. SIZEMORE, M.D.
In 1972 Baum (1) reported an abnormal histamine skin test in a patient with medullary thyroid carcinoma, pheochromocytoma, and mucosal neuromas—multiple endocrine neoplasia, type 2b (2); there was no flare around the wheal. Baum proffered two hypothetical explanations for the defect: an abnormal axon reflex due to a neural lesion; and rapid degradation of histamine by a substance, such as histaminase, secreted by medullary thyroid carcinoma. Herein we confirm Baum's finding of an abnormal response to histamine skin test in patients with multiple endocrine neoplasia, type 2b; report diffuse enlargement of cutaneous nerves in these patients; and suggest a possible
CARNEY JA, HAYLES AB, PEARSE AGE, PERRY HO, SIZEMORE GW. Abnormal Cutaneous Innervation in Multiple Endocrine Neoplasia, Type 2b. Ann Intern Med. ;94:362–363. doi: 10.7326/0003-4819-94-3-362
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Published: Ann Intern Med. 1981;94(3):362-363.
Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology, Neurology.
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