PETER A. SIMKIN, M.D.
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To the editor: The recent short paper of Wortmann and Fox (1) provides valuable new data on uric acid excretion in man. It is most important, however, that these findings not be overinterpreted. The authors' claim of a high correlation between 24-hour urinary uric acid excretion and the rate of uric acid synthesis rests on two series in which purine intake was rigidly restricted before and during the turnover study (2, 3). The authors' patients, in contrast, received a regular hospital diet. To this time there are no data to indicate that uric acid turnover will correlate highly with 24-hour
SIMKIN PA. Uric Acid Excretion. Ann Intern Med. 1981;94:417. doi: 10.7326/0003-4819-94-3-417_1
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Published: Ann Intern Med. 1981;94(3):417.
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