J. L. TERUEL, M.D.; P. GARCIA-COSMES, M.D.; R. MARCEN, M.D.; J. ORTUÑO, M.D.
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To the editor: The extent of renal effects of cimetidine is not clear. Studies have concluded that it does not significantly alter glomerular filtration, renal regulation of acid-base equilibrium, or the capacity for urinary concentration (1, 2). Small increases in serum creatinine detected in some patients (3) have been attributed to a diminution of tubular secretion of creatinine, which competes with the drug for a common secretory mechanism (2). In any case, renal effects are not considered a clinical problem during treatment with cimetidine given in normal doses (4). Seidelin (5) has recently reported a case of acute renal failure secondary to cimetidine. We have seen two patients with nonoliguric acute renal failure
TERUEL JL, GARCIA-COSMES P, MARCEN R, et al. Renal Failure with Cimetidine. Ann Intern Med. 1981;94:545. doi: 10.7326/0003-4819-94-4-545_1
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Published: Ann Intern Med. 1981;94(4_Part_1):545.
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