DAVID M. NATHAN, M.D.; LLOYD AXELROD, M.D.; JEFFREY S. FLIER, M.D.; DANIEL B. CARR, M.D.
Three patients with antibody-mediated insulin resistance were treated with U-500 regular insulin subcutaneously. Insulin requirements decreased dramatically (55% to 75%) when therapy was changed from U-100 NPH pork to equivalent doses of U-500 regular pork insulin. There was no difference in antibody affinity for the insulin in these two preparations as shown by competition experiments. These observations demonstrate that U-500 insulin is a useful alternative in the treatment of antibody-mediated insulin resistance. The mechanism for this effect is yet to be determined.
NATHAN DM, AXELROD L, FLIER JS, et al. U-500 Insulin in the Treatment of Antibody-Mediated Insulin Resistance. Ann Intern Med. 1981;94:653–656. doi: https://doi.org/10.7326/0003-4819-94-5-653
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Published: Ann Intern Med. 1981;94(5):653-656.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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