ADRIAAN W. DEKKER, M.D.; MAJA ROZENBERG-ARSKA, M.D.; JAN J. SIXMA, M.D.; JAN VERHOEF, M.D.
Fifty-two patients with acute nonlymphocytic leukaemia were studied during remission induction treatment in a randomized trial to ascertain the effect of prophylactic oral trimethoprim-sulfamethoxazole on infection and fever rate. A decrease in the total number of acquired infections was found (16 infections in the group given trimethoprim-sulfamethoxazole versus 31 in the control group, p < 0.01). The number of patients without any infection in the trimethoprim-sulfamethoxazole group was 13 compared to only three in the control group (p < 0.01). Patients in the trimethoprim-sulfamethoxazole group needed parenteral antibiotics during 33% of the days they were granulocytopenic compared to 61% of these days for patients in the control group. However, six of nine bacteriologically documented infections in the trimethoprim-sulfamethoxazole group were caused by resistant microorganisms compared to two out of 20 in the control group.
DEKKER AW, ROZENBERG-ARSKA M, SIXMA JJ, et al. Prevention of Infection by Trimethoprim-Sulfamethoxazole Plus Amphotericin B in Patients with Acute Nonlymphocytic Leukaemia. Ann Intern Med. 1981;95:555–559. doi: https://doi.org/10.7326/0003-4819-95-5-555
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Published: Ann Intern Med. 1981;95(5):555-559.
Hematology/Oncology, Infectious Disease, Leukemia/Lymphoma.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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