STEVEN M. WAGNER, M.D.
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To the editor: I read with great interest the paper by Hoofnagle and associates (1). Information on the natural history of type B chronic hepatitis is welcomed by anyone treating patients with chronic liver disease.
I take exception to their recommendations on therapy with corticosteroids in patients with type B hepatitis. Corticosteroids have not been shown to be efficacious in treating type B hepatitis regardless of the severity of histologic changes. A previous paper (2) by many of the same authors as the recent Annals article did recommend treatment with corticosteroids for symptomatic patients who had severe histologic abnormalities and
WAGNER SM. Seroconversion from Hepatitis B e Antigen in Chronic Type B Hepatitis. Ann Intern Med. 1981;95:656–657. doi: https://doi.org/10.7326/0003-4819-95-5-656
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Published: Ann Intern Med. 1981;95(5):656-657.
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