ROBERT A. GILL, M.D.; GERALD R. ONSTAD, M.D.; JOSEPH M. CARDAMONE, M.D.; DANIEL C. MANEVAL, P.A.; HATTON W. SUMNER, M.D.
Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of intense sinusoidal engorgement. Although this disease was clinically reversible, some subintimal fibrosis about the terminal hepatic veins persisted. This case presented a unique opportunity to observe the histologic features of clinically reversible hepatic veno-occlusive disease over time, and may be the first case of veno-occlusive disease related solely to 6-thioguanine.
GILL RA, ONSTAD GR, CARDAMONE JM, et al. Hepatic Veno-Occlusive Disease Caused by 6-Thioguanine. Ann Intern Med. 1982;96:58–60. doi: https://doi.org/10.7326/0003-4819-96-1-58
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Published: Ann Intern Med. 1982;96(1):58-60.
Gastroenterology/Hepatology, Liver Disease.
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