MICHAEL R. RUDNICK, M.D.; CHRISTINE P. BASTL, M.D.; I. B. ELFENBEIN, M.D.; ROBERT A. SIROTA, M.D.; MELVIN YUDIS, M.D.; ROBERT G. NARINS, M.D.
Acute, partially reversible interstitial nephritis and azotemia developed in two patients after cimetidine treatment. Renal biopsy in Patient 2 showing acute interstitial nephritis and the recrudescence of azotemia after Patient 1's inadvertant rechallenge with the drug strongly indicate cimetidine's nephrotoxicity. The relation of the enhanced delayed hypersensitivity caused by H2-receptor blockade is proposed as a possible mechanism by which cimetidine causes interstitial nephritis.
RUDNICK MR, BASTL CP, ELFENBEIN IB, et al. Cimetidine-Induced Acute Renal Failure. Ann Intern Med. 1982;96:180–182. doi: https://doi.org/10.7326/0003-4819-96-2-180
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Published: Ann Intern Med. 1982;96(2):180-182.
Acute Kidney Injury, Nephrology.
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