SAMUEL CHARACHE, M.D.; M. EULALIA HARBAUGH, M.T.
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To the editor: We were surprised at the letter from Palmer and associates (1) reporting that storage of blood at 4 °C in commercial siliconized borosilicate tubes led to significant shortening of the prothrombin time in patients receiving warfarin sodium. Because storage artifacts would add one more hazard to an already difficult situation, we repeated their experiment.
Blood from four patients, three of them receiving warfarin, was stored at either 4 C or 23 °C in partially siliconized glass Vacutainer tubes (Becton Dickinson #6464, Sharon, Massachusetts; 3.2% buffered citrate), and then tested at 1-hour intervals in a Lancer Coagulizer II
CHARACHE S, HARBAUGH ME. Variables Affecting Measurement of Prothrombin Time. Ann Intern Med. ;96:378. doi: 10.7326/0003-4819-96-3-378_1
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Published: Ann Intern Med. 1982;96(3):378.
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