JAMES B. PUCKETT, M.D.; M. ROBERT COOPER, M.D.; JOHN J. STUART, M.D.; WALLACE C. WU, M.B.B.S.; J. MICHAEL STERCHI, M.D.
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To the editor: Pyrimethamine and sulfadiazine are useful in treating ocular toxoplasmosis. We recently cared for a patient who was treated for ocular toxoplasmosis with pyrimethamine and sulfadiazine and developed scalp alopecia, bone marrow hypoplasia, and a malabsorption syndrome with total villous atrophy of the jejunum.
A 28-year-old woman was treated in 1974 for occular toxoplasmosis with pyrimethamine and sulfadiazine and developed scalp alopecia and diarrhea that persisted for 1 month. In August 1979 she had increased activity of her ocular toxoplasmosis and again was treated with pyrimethamine and sulfadiazine. On the third day of therapy she developed fever, scalp
PUCKETT JB, COOPER MR, STUART JJ, WU WC, STERCHI JM. Pyrimethamine, Sulfadiazine , and Villous Atrophy of the Jejunum. Ann Intern Med. ;96:380. doi: 10.7326/0003-4819-96-3-380_1
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Published: Ann Intern Med. 1982;96(3):380.
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