DAVID F. GARDNER, M.D.; ROBERT L. CARITHERS Jr., M.D.; ROBERT D. UTIGER, M.D.
Serum thyroid hormones and thyroid hormone binding were sequentially measured in 20 patients with acute hepatitis B infection. Criteria to select patients consisted of a positive test for hepatitis B surface antigen, aspartate aminotransferase (AsAT) concentration greater than 400 U/L during the acute illness, and available serum specimens after recovery. The mean serum thyroxine (T4) concentration (±SE) was 12.5 ± 0.6 µ/dL during acute infection and 7.4 ± 0.3 µ/dL after recovery (p < 0.001), whereas mean free T4 index values did not significantly differ. The mean serum thyroxine-binding globulin (TBG) concentration was significantly increased (p < 0.001) during acute illness and accounted for the reversible increase in the thyroid-hormone-binding capacity of serum and the increased serum T4 concentrations. The rise in serum TBG correlated with the rise in AsAT during the acute illness (p < 0.04) suggesting nonspecific release of these proteins from injured hepatocytes. The mean free triiodothyronine (T3) index was decreased during acute hepatitis (p < 0.001) and returned to normal after recovery, indicating that acute hepatitis B infection, like other nonthyroidal illnesses, is associated with decreased T4 to T3 conversion in peripheral tissues.
GARDNER DF, CARITHERS RL, UTIGER RD. Thyroid Function Tests in Patients with Acute and Resolved Hepatitis B Virus Infection. Ann Intern Med. 1982;96:450–452. doi: https://doi.org/10.7326/0003-4819-96-4-450
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Published: Ann Intern Med. 1982;96(4):450-452.
Endocrine and Metabolism, Infectious Disease, Thyroid Disorders.
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