DAVID BAR-OR, M.D.; JOHN A. MARX, M.D.; JAMES T. GOOD JR., M.D.
This content is PDF only. Please click on the PDF icon to access.
To the editor: High-altitude pulmonary edema develops in certain unacclimatized and susceptible persons acutely exposed to extreme elevation. Since its original report the clinical manifestations have been well described, but despite numerous speculations the pathogenesis of this disorder remains unclear (1-3).
We describe here an otherwise healthy man who presented with high-altitude pulmonary edema, in whom plasma beta endorphins were measured and found to be significantly elevated. Dramatic improvement in the patient's hypoxemia and clinical course occurred after administration of naloxone. We postulate that this opiate antagonist may be beneficial in the treatment of this disorder.
A 22-year-old white man,
BAR-OR D, MARX JA, GOOD JT. Naloxone, Beta Endorphins, and High-Altitude Pulmonary Edema. Ann Intern Med. 1982;96:684–685. doi: https://doi.org/10.7326/0003-4819-96-5-684_3
Download citation file:
Published: Ann Intern Med. 1982;96(5):684-685.
Copyright © 2020 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use