DONNA MILDVAN, M.D.; USHA MATHUR, M.D.; ROGER W. ENLOW, M.D.; PAUL L. ROMAIN, M.D.; ROBERT J. WINCHESTER, M.D.; CHARLOTTE COLP, M.D.; HENRY SINGMAN, M.D.; BERNARD R. ADELSBERG, M.D.; ILYA SPIGLAND, M.D.
A syndrome of opportunistic infections and acquired immune deficiency occurred among four previously healthy homosexual men. Fever, leukopenia, and diminished delayed hypersensitivity were accompanied by various degrees of proctitis, perianal ulcerations, and lymphadenopathy. The infectious agents included Pneumocystis carinii, Cryptococcus neoformans, Candida albicans, herpes simplex virus, and cytomegalovirus. The immune deficiency was characterized as a persistent and profound selective decrease in the function as well as number of T lymphocytes of the helper/inducer subset and a possible activation of the suppressor/cytotoxic subset. Three patients died despite aggressive anti-infective therapy.
MILDVAN D, MATHUR U, ENLOW RW, ROMAIN PL, WINCHESTER RJ, COLP C, et al. Opportunistic Infections and Immune Deficiency in Homosexual Men. Ann Intern Med. 1982;96:700–704. doi: 10.7326/0003-4819-96-6-700
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Published: Ann Intern Med. 1982;96(6_part_1):700-704.
DOI: 10.7326/0003-4819-96-6-700
Infectious Disease.
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