ALLEN LEE PARIS, M.D., M.S.; LOREEN A. HERWALDT, M.D.; DEBORAH BLUM, M.D.; GEORGE P. SCHMID, M.D.; KATHRYN N. SHANDS, M.D.; CLAIRE V. BROOME, M.D.
Pathologie changes in 12 fatal cases of toxic shock syndrome occurred in the vagina, cervix, lung, liver, and kidney. Desquamation and ulceration of the cervical and vaginal mucosa were seen in all six cases where adequate specimens were submitted. Hyaline membrane formation characteristic of "shock lung" was found in all lung tissues. Periportal inflammation was found in all liver specimens and acute tubular necrosis was seen in eight of the 12 kidney specimens. Although not specific for toxic shock syndrome, the findings are consistent with the hypothesis that the illness is caused by a staphylococcal toxin.
PARIS AL, HERWALDT LA, BLUM D, SCHMID GP, SHANDS KN, BROOME CV. Pathologic Findings in Twelve Fatal Cases of Toxic Shock Syndrome. Ann Intern Med. ;96:852–857. doi: 10.7326/0003-4819-96-6-852
Download citation file:
Published: Ann Intern Med. 1982;96(6_Part_2):852-857.
Multi-Organ Failure and Sepsis, Pulmonary/Critical Care.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use