J. R. STOCKIGT, M.D.; J. W. BARLOW, M.SC.
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To the editor: The report by Silverberg and Premachandra (1) identifies a further euthyroid kindred with circulating thyroxine (T4) excess not due to an increase in levels of thyroxine-binding globulin. The authors point out similarities to other reported families (2-4) in whom a high total T4 level was associated with normal free T4 value. Their report differs in that both total and free T4 levels are increased in the two subjects studied. It is surprising to us that such a finding can be attributed to a binding abnormality. In view of the common authorship, it is puzzling that they do
STOCKIGT JR, BARLOW JW. Familial Thyroxine-Excess Syndrome. Ann Intern Med. ;97:143–144. doi: 10.7326/0003-4819-97-1-143_2
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Published: Ann Intern Med. 1982;97(1):143-144.
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