NEIL H. WHITE, M.D.; DONALD SKOR, M.D.; JULIO V. SANTIAGO, M.D.
We evaluated a practical closed-loop system of insulin delivery consisting of hourly blood glucose determinations using glucose oxidase reagent strips and an intravenous infusion of insulin controlled by a commonly available controller. In 25 insulin-dependent diabetic subjects, this system was successful in achieving and maintaining near euglycemia (blood glucose, 101 ± 2 mg/dL, mean ± SE) in the fasting state between 0200 and 0800 hours. This system may be useful in the management of insulin-dependent diabetic patients in various hospital settings. Also, in 10 subjects treated subsequently using a continuous subcutaneous insulin infusion, the mean hourly insulin infusion rate using the described system correlated well (r = 0.92) with the optimal overnight basal rate needed during continous subcutaneous insulin infusion therapy.
WHITE NH, SKOR D, SANTIAGO JV. Practical Closed-Loop Insulin Delivery: A System for the Maintenance of Overnight Euglycemia and the Calculation of Basal Insulin Requirements in Insulin-Dependent Diabetics. Ann Intern Med. 1982;97:210–213. doi: https://doi.org/10.7326/0003-4819-97-2-210
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Published: Ann Intern Med. 1982;97(2):210-213.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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