ROBERT TUCKER, M.S., R.PH.
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To the editor: Gibson and associates (1) reported a case of methemoglobinemia induced by nitroglycerin given intravenously. I note that doses as high as 30 µg/kg body weight · min were needed before there was clinical improvement. I am not aware of cases in the medical literature in which doses above 5 to 7 µg/kg body weight · min were needed for any cardiovascular problem for which nitroglycerin given intravenously is effective. One aspect not addressed by the authors was the possibility of an effect of the intravenous delivery system. A number of reports have described drug instability and binding
TUCKER R. Nitroglycerin Dosage and Polyethylene Tubing. Ann Intern Med. ;97:619. doi: 10.7326/0003-4819-97-4-619_2
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Published: Ann Intern Med. 1982;97(4):619.
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