JUDITH C. AHRONHEIM, M.D.
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To the editor: Metoclopramide, a central dopamine receptor antagonist, has potent cholinergic stimulatory effects on the gastrointestinal tract and is used for a variety of motility related symptoms. Reported extrapyramidal side effects of the drug include acute dystonic reactions, parkinsonism, and tardive dyskinesias (1-5), the last two occurring predominantly in the elderly. I report an elderly woman in whom short-term metoclopramide induced an acute extrapyramidal reaction in which essential-type tremor was the predominant feature.
An 86-year-old woman with postprandial belching and abdominal bloating was treated with oral metoclopramide, 10 mg three times a day. Her gastrointestinal symptoms were relieved, but
AHRONHEIM JC. Metoclopramide and Tremor. Ann Intern Med. 1982;97:621. doi: https://doi.org/10.7326/0003-4819-97-4-621_1
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Published: Ann Intern Med. 1982;97(4):621.
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