KEVIN R. WHEELAN, M.D.; BARRY COOPER, M.D.; MARVIN J. STONE, M.D.
Various adverse reactions to sulfa drugs have been documented by numerous reports (1). Several distinct hematologic abnormalities associated with the use of sulfasalazine (Azulfidine; Pharmacia Laboratories, Piscataway, New Jersey) have been reported including hemolytic anemia, thrombocytopenia, and fatal agranulocytosis. We describe a patient with Crohn's disease who presented with agranulocytosis, erythroid hypoplasia, and marked marrow plasmacytosis. All these findings resolved promptly after sulfasalazine treatment was discontinued.
A 28-year-old black man developed bloody diarrhea in December 1980. Findings on physical examination were normal. Laboratory data included a leukocyte count of 12 900/mm3 with normal differential, and a hematocrit of 29%. Findings
WHEELAN KR, COOPER B, STONE MJ. Multiple Hematologic Abnormalities Associated with Sulfasalazine. Ann Intern Med. ;97:726–727. doi: 10.7326/0003-4819-97-5-726
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Published: Ann Intern Med. 1982;97(5):726-727.
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