P.K. KUTTY, M.B.; K.R.K. RAMAN, M.D.; K. HAWKEN, M.D.; J.A. BARROWMAN, M.B.
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To the editor: 5-Aminosalicylic acid is believed to be the active metabolite of sulfasalazine which is used widely in the treatment of chronic inflammatory bowel disease (1, 2). Double-blind controlled trials have shown that retention enemas containing 5-aminosalicylic acid are effective in inducing remission from active ulcerative colitis (3, 4). Unlike sulfasalazine, topical 5-aminosalicylic acid is believed to be free of side effects. We report two cases of accelerated hair loss from the scalp associated with 5-aminosalicylic acid enema therapy for ulcerative proctitis.
A 24-year-old white man was found in June 1981 to have idiopathic distal ulcerative colitis. The patient's
KUTTY P, RAMAN K, HAWKEN K, et al. Hair Loss and 5-Aminosalicylic Acid Enemas. Ann Intern Med. 1982;97:785–786. doi: 10.7326/0003-4819-97-5-785_2
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Published: Ann Intern Med. 1982;97(5):785-786.
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