ROBERT DeCHRISTOFORO, M.S., R.Ph.; BRIAN J. CORDEN, M.D., Ph.D; JERRY C. HOOD, M.S., R.Ph.; PREM K. NARANG, Ph.D.; IAN T. MAGRATH, M.B.
Opiate analgesics, including morphine sulfate, are often the mainstay of pain control in the terminally ill cancer patient (1, 2). There have been recent reports of the safe and effective administration of morphine sulfate as continuous intravenous infusion (3-6). Respiratory depression is the major determinant of maximal dosage. Other side effects such as constipation, sleepiness, and hallucinations are well known, but not life-threatening.
A patient with Ewing's sarcoma had pain poorly controlled with a continuous morphine infusion of up to 6.8 mg/kg body weight · h. This dose was in excess of any dose reported in the literature. The patient's
DeCHRISTOFORO R, CORDEN BJ, HOOD JC, NARANG PK, MAGRATH IT. High-Dose Morphine Infusion Complicated by Chlorobutanol-Induced Somnolence. Ann Intern Med. ;98:335–336. doi: 10.7326/0003-4819-98-3-335
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Published: Ann Intern Med. 1983;98(3):335-336.
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